|
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.
|
30239831 |
2019 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have now established the PsiNCF1 to NCF1 ratio for a significant number of IBD patients (n = 488) and control subjects (n = 181) and show that there is no statistically significant difference between the frequency of the 1:1 ratio in CD (11.2%) or UC (12.2%) patients and controls (13.4%).
|
15626894 |
2004 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
AKAP13 and TB10 regions may represent potential new genomic markers for PTC and cancer progression.
|
22161024 |
2012 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tuberculosis in Pap samples with emphasis on LBC: Caught only when thought.
|
29193907 |
2018 |
|
trachomatis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.
|
16959883 |
2006 |
|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses identify new loci influencing intraocular pressure.
|
29617998 |
2018 |
|
T-Cell Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, using the murine LBC T-cell lymphoma, we found that cyclophosphamide significantly increased EVs yield.
|
30777349 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Sarcomatoid Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
|
Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
|
28319090 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because AKAP plays a major role in protein kinase A and Rho protein mediated signaling, functional studies are underway to elucidate the significance of tTG-AKAP13 interaction in prostate cancer.
|
16301118 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, genetic alterations within the candidate cancer susceptibility gene AKAP13 would be expected to provoke a constitutive Rho signalling, thereby facilitating the development of cancer.
|
16234258 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In 2008 the Ludwig Boltzmann Cluster Oncology (LBC ONC) was established on the basis of two previous Ludwig Boltzmann Institutes working in the field of hematology and cancer research.
|
30006759 |
2018 |
|
Peripartum cardiomyopathy
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy.
|
21665988 |
2011 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
AKAP13 and TB10 regions may represent potential new genomic markers for PTC and cancer progression.
|
22161024 |
2012 |
|
Papillary Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
|
Obsessive-Compulsive Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression.
|
29653158 |
2018 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression.
|
29653158 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Amplification in the AKAP13 region was demonstrated in 42.9% and 15.4% of the cases with local or with distant metastasis, respectively, while no amplification was detected in non-metastatic cases.
|
22161024 |
2012 |
|
Myeloproliferative disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, the concept of preleukemic (premalignant) neoplastic stem cells (pre-L-NSC) was coined by the LBC ONC and was tested in myelodysplastic syndromes and myeloproliferative neoplasms.
|
30006759 |
2018 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, the concept of preleukemic (premalignant) neoplastic stem cells (pre-L-NSC) was coined by the LBC ONC and was tested in myelodysplastic syndromes and myeloproliferative neoplasms.
|
30006759 |
2018 |